Non-small cell lung cancer (NSCLC) is responsible for 85% of lung cancer cases and is still the primary cause of cancer-related deaths. Conventional treatments offer limited efficacy, necessitating novel therapeutic strategies to overcome drug resistance. This study isolated and characterized compound
1
from
Artemisia annua
, confirmed by nuclear magnetic resonance (NMR) and high-resonance electrospray ionization mass spectroscopy (HR-ESI-MS). To enhance its therapeutic potential, we developed PEI-FA@CP1@1, a manganese-based coordination polymer (CP1) encapsulating compound
1
, further modified with folic acid (FA) and polyethyleneimine (PEI). This targeted drug delivery system demonstrated effective NSCLC cell inhibition via apoptosis induction, providing a promising low-toxicity therapeutic approach. Additionally, AI-driven (Molecular Deep Q-Network) MolDQN screening identified potential anticancer compounds related to compound
1
, accelerating drug discovery and offering a new strategy for precision cancer therapy.
Cite this Article (APA)
Qiong, W., Tongran, L., Deyue, J., Lili, D., Yushu, W., Tian, J., Hui, H., Haoyuan, C., Xiaodong, H., Xiaodi, Y., Zhongqing, Q., Fei, L., Xiaojing, W., Fuliang, C. (2026). Polyethyleneimine-Folic acid modified manganese coordination polymer delivery platform for artemisinin in the treatment of non-small cell lung cancer. Arabian Journal of Chemistry. https://doi.org/10.25259/ajc_665_2025
