A novel nomogram for the prediction of perforation during endoscopic submucosal dissection for colorectal neoplasms

Abstract

Background:
High perforation risk hinders the widespread adoption of ESD for colorectal neoplasms. This study was performed to determine the risk factors of colorectal endoscopic submucosal dissection (ESD)-induced perforation and develop a predictive model.


Methods:
A total of 1046 colorectal neoplasms in 1011 patients were retrospectively enrolled from January 2011 to December 2021, in a single tertiary center as the derivation cohort. We identified independent risk factors for perforation using univariate analysis and multi-variate logistic regression. A nomogram was developed based on the logistic regression model and prospectively applied to 266 colorectal neoplasms as the validation cohort. The performance of the predictive model was evaluated with the receiver operating characteristic curve, calibration plot, and decision curve analysis.


Results:

Independent pre-operative factors for colorectal ESD-induced perforation were tumor located in the left colon [odds ratio (OR) 2.39,
P
= 0.040], size ≥ 40 mm (OR 3.36,
P
< 0.001), ≥2/3 circumference (OR 7.55,
P
= 0.004), located across folds (OR 6.26,
P
< 0.001), and laterally spreading tumor (non-granular type, OR 2.34,
P
= 0.029; granular type, OR 2.46,
P
= 0.021). The nomogram model incorporating the pre-operative factors performed well in both the derivation and validation cohorts (areas under the curve of 0.750 and 0.806, respectively). Decision curve analysis demonstrated that the clinical benefit of the nomogram was favorable.



Conclusions:
The novel nomogram, developed and prospectively validated, incorporating tumor size, location, and morphology can successfully predict perforation during ESD for colorectal neoplasms.