Antimicrobial Efficacy of Quercetin against Biofilm Production by <i>Staphylococcus Aureus</i>

Background: The bad administration of antibiotics represents a worldwide health issue as it leads to the emergence of multidrug-resistant microbes including Staphylococcus aureus, which represents a significant challenge for public health since it increases its ability to cause potentially fatal infections. Objective: This study aims to reduce the bacterium’s ability to form biofilms and antibiotic resistance. Methods: Thirty Staphylococcus aureus isolates were isolated from different clinical samples in Baghdad city and their ability to form biofilm was tested using the Microtiter Plate method. Out of 30 isolates, eight strong biofilm producer isolates were further investigated for their antimicrobial activity and biofilm formation with the impact of quercetin. Results: The results showed the ability of quercetin to inhibit bacteria and had an antibiofilm activity that was determined through investigation of the minimal inhibitory concentration by taking different concentrations. The anti-biofilm activity of quercetin was determined for the eight isolates and the results showed that biofilm formation was reduced by 100% using quercetin at a concentration of 3.1 mg/ml. Conclusions: Quercetin represents a suitable alternative to synthetic antimicrobials with the increased rate of drug-resistant bacteria among clinical samples with highly effective ability as anti-biofilm formation among strong biofilm producers of S. aureus.