Outcome of stereotactic lesioning surgery for the treatment of Parkinson’s disease

Abstract

Background
Movement disorders are group of functional disorders related to basal ganglia dysfunction like Parkinson’s disease. Many management modalities appeared in history like lesioning surgery, L-dopa and Deep brain stimulation (DBS).


Objective
To assess outcome of stereotactic lesioning surgery for patients with primary Parkinson’s disease.


Methods
This study is conducted on 20 Parkinsonian patients to undergo surgery at El Galaa Military hospital to control their symptoms. Patients underwent GPI and VIM lesioning according to their symptoms.


Results
The Patients had a notable reduction in UPDRS III, with improvements seen in the “off” and “on” states. The study confirms that both GPI and VIM lesioning surgeries control the symptoms in patients with medically refractory Parkinson’s disease.


Conclusion
In selected patients with Parkinson’s disease, GPI and VIM lesioning are effective for controlling motor symptoms, dyskinesias, and motor fluctuations. GPI and VIM lesioning also provide functional improvements, controlling contralateral tremors, levodopa-induced dyskinesias, rigidity and bradykinesia.