Abstract
Background
A well-recognized connection was found between oxidative stress and rheumatoid arthritis (RA). Since autoimmune illness, as RA is typified by persistent systemic inflammation, oxidative stress indicators offer a promising extra option for evaluating the activity and prognosis of RA.
Aim
To assess serum malondialdehyde (MDA) level as a marker of oxidative stress in RA patients concerning disease activity.
Results
This case–control study revealed a statistically significant increase among the patient group than the control group regarding serum MDA. MDA positively correlated with ESR, CRP, DAS-28 score, and morning stiffness. The optimal cut-off point of serum MDA recognized patient group was > 16.21 nmol/ml with a sensitivity of 100% and specificity of 100.0%.
Conclusion
Measuring MDA levels in RA patients may be useful for monitoring their activity level and oxidative stress.
Cite this Article (APA)
Ghada, A. N., Nehal, E. S., Dalia, M. E. E. M., Marwa, A. K. (2024). Serum malondialdehyde as a marker of oxidative stress in rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation. https://doi.org/10.1186/s43166-024-00275-4
