Background
Osteoarthritis (OA) and osteoporosis (OP) are the two predominant skeletal diseases linked to aging. The relationship between knee osteoarthritis, osteoporosis, and vitamin D insufficiency is not yet well comprehended and continues to be a topic of debate. This cross-sectional study examined the association between the functional, clinical, and radiographic characteristics of primary knee osteoarthritis and both bone mineral density and serum vitamin D levels in postmenopausal women.
Results
There was a significant correlation between vitamin D levels and the knee osteoarthritis flare-up score (KOFUS) score (p = 0.005). A substantial association was found between bone mineral density as reflected by the T score and knee osteoarthritis flare-up score, WOMAC score, and Kellgren and Lawrence scores: p = 0.014, p < 0.05, and 0.001, respectively. A significant association was observed between bone mineral density (BMD) and the five-times sit-to-stand and 10-m walk speed tests.
Conclusion
Vitamin D deficiency has a significant impact on knee osteoarthritis severity and activity in postmenopausal women. A significant correlation exists between osteoporosis and flare-ups of knee osteoarthritis, along with both clinical and radiographic severity and functional status in postmenopausal women.
Cite this Article (APA)
Sahar, W. E., Abdel, W. S. E. D. E. B., Mohamed, H. F., Noha, H. I. (2025). Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study. Egyptian Rheumatology and Rehabilitation. https://doi.org/10.1186/s43166-025-00340-6
