Association of Carnosinase-2 Single Nucleotide Polymorphism (rs 6566810) with Serum Carnosine and Carnosinase-2 Levels in Type 2 Diabetics with Cardiovascular Diseases in Iraq

Carnosine have several important biological activities, as implicated by its effects on several diseases such cardiovascular disease, diabetes mellitus, cancer and can play important role in improving the functional capability during ischemic circumstances. Carnosine levels in diabetes patients may be affected by genetic variants in the carnosinase-2 gene, which may also be linked to development of cardiovascular problems. The purpose of this study was to examine the impact of the Carnosinase-2 gene polymorphism SNP (rs 6566810) on serum levels of carnosine and carnosinase-2 and their relationship to CVD in type 2 diabetes (T2DM) patients with and without CVD compared to healthy controls