Comparative Carvedilol Nanomicelle Preparation Method: Thin-Film Hydration and Direct Dissolution using Soluplus and PVP K-25

     The present work aims to formulate carvedilol as nanomicelle and study variables effect on the particle size of nanomicelle, and on the entrapment efficiency (EE%). The formulations were performed by two methods; thin film hydration method and direct dissolution method using soluplus® and polyvinylpyrrolidone (PVP K-25) as polymers. The results revealed that formulations prepared by direct dissolution method exhibits lower size and higher EE% as compared with thin film hydration method, it was found that soluplus® produces larger size of nanomicelle and lower EE% as compared with PVP K-25, it was found that as the amount of polymer raised, the size of nanomicelle increased in both polymers, the effect of solvent indicates that methanol solvent produced lower particle size as compared with ethanol. From all the results obtained, we conclude that the direct dissolution was the best method for preparation of carvedilol nanomicelle and PVP K-25 in a concentration of 1:5 considered the best polymer that gave the best result for preparation concerning nanomicelle size, and EE%.