Serum Uric Acid and LDL-C in Yemeni Type 2 Diabetic Men: Insights from a Conflict-Zone Case-Control Study

Background: Type 2 diabetes mellitus (T2DM) is a major public health concern due to its association with various cardiovascular risk factors. Among these risk factors, elevated serum uric acid levels have gained increasing attention as a potential contributor to cardiovascular disease (CVD). While uric acid’s role in dyslipidemia is debated, data from Middle Eastern populations remain scarce.


Objective: This study aimed to investigate the association between serum uric acid levels and certain cardiovascular risk factors, including lipid profile parameters, in male patients with T2DM.


Methods: This case-control study, adapted for conflict-zone conditions, enrolled 100 Yemeni males (50 T2DM and 50 controls) in Al-Dhalea. Fasting blood was analyzed for SUA (uricase-PAP), lipids, and glucose using solar-powered and Barricor tube protocols.


Results: T2DM patients had higher SUA (6.56 vs. 5.13 mg/dL, p<0.001) and LDL-C (114.9 vs. 72.9 mg/dL, p<0.001), with a strong SUA-LDL-C correlation (β=0.58, p=0.002). Triglycerides showed no association (p=0.147).


Conclusion: Elevated SUA is independently associated with LDL-C in Yemeni T2DM males, suggesting SUA as a modifiable CVD risk marker.