Evaluation of (HbA1c, Creatinine, Dopamine receptor2, Insulin, Glutathione, Lipidperoxidase) in type 2 diabetes mellitus patients

The dopamine receptor, often known as DA, is crucial in the body's regulation of insulin production. The patient group had significantly lower mean and standard deviation values for Dopamine receptors than the control group. In this study, regarding the Dopamine receptor mean (SD), patients with type 2 diabetes mellitus and control groups had values of 2.48 (1.17) and 102.71 (543.30), respectively. The insulin means (SD) for the patient and control groups were 258.0601 (44.35) and 119.8709 (37.075), respectively. The insulin concentration between the patients with type 2 diabetes mellitus and control groups differ significantly, as indicated by a p-value of < 0.05. Based on this research, individuals with the illness exhibited reduced concentrations of Dopamine receptor 2. The significant disparity, as evidenced by a p-value below 0.05, suggests that this divergence is highly unlikely to be a chance occurrence. This result aligns with the notion that the pancreas secretes insulin when blood glucose levels are elevated. The liver enzymes are AST ALT and T2DM patients. The mean values of ALT and AST were considerably higher in the T2DM group than in humans without T2DM (P= 0.001). The findings of this study demonstrate a significant reduction in Dopamine receptor 2 levels and an increase in insulin concentrations in patients with type 2 diabetes mellitus (T2DM) compared to control groups. The elevated levels of liver enzymes AST and ALT in T2DM patients further suggest a potential link between altered biochemical factors and the disease's pathophysiology. These disparities, confirmed by statistically significant p-values, underscore the critical role of Dopamine receptor and liver enzymes in the regulation of insulin production and glucose metabolism.