Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients

Background::
The association between visceral obesity and insulin resistance establishes an alternative risk for the onset of type 2 diabetes mellitus. The
infiltration of macrophages in the visceral fatty tissue and the unreliable generation of adipokines are associated with mechanisms directing the
progress of insulin resistance.


Objective::
The objective of the study was to observe the relationship between visceral fat-associated adipokines and biochemical variables in central obese
type 2 diabetic patients.


Methods::
This study included 100 central obese subjects (both genders) aged 30-60 years newly diagnosed with type 2 diabetes mellitus. Out of the 100
participants, 73 were male and 27 were female. Serum adipokines were analyzed using an enzyme-linked immunosorbent assay. Biochemical
parameters were assessed using the Cobas® 6000 analyzer, while HbA1c levels were determined through high-performance liquid chromatography.


Results::
The results showed a significant relationship (p < 0.05) between the adipokines and HbA1c, fasting, and postprandial blood glucose levels. The
results indicated a significant association (p < 0.05) between the adipokines and lipid profile with varying degrees in central obese type 2 diabetic
subjects.


Conclusion::
The relationship between visceral fat-associated adipokines and metabolic variables may influence the metabolic pathways in central obese type 2
diabetic patients. The adipokines are strong predictors for the intensification of diabetic risk and can be used as a diagnostic tool for risk
assessment in the central obese population.