Involvement of Molecular Mechanism and Biological Activities of Pemirolast: A Therapeutic Review

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This review paper aims to investigate the therapeutic benefits of pemirolast across different medical conditions, including asthma, allergic rhinitis,
cancer, conjunctivitis, etc. The prevalence of allergic conditions has risen in recent decades, primarily attributed to environmental factors. This
paper explores the role of pemirolast in managing and mitigating these diseases, shedding light on its potential applications in the context of
evolving environmental influences.


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This review paper investigates the diverse biological activities exhibited by pemirolast, encompassing its roles as an antimicrobial, analgesic,
antiviral, anti-inflammatory, antioxidant, antihistamine, mast cell stabilizer, anti-tubercular, anticancer, anti-asthmatic, anti-malarial, diuretic, antianxiety,
and antifungal agent. The positive outcomes of pemirolast application in various diseases are highlighted, showcasing its potential across a
spectrum of medical conditions.


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The pharmacological impact of pemirolast extends to diverse inflammatory mediators, enzymes, and hormones associated with various diseases.
Pemirolast demonstrates inhibitory effects on key elements such as eosinophil activation, histamine, leukotriene, IgE, mast cells, basophils,
prostaglandin, interleukin, T-helper cells, macrophage T-cells, neutrophils, tryptase, T-lymphocytes, interferons I-III, Amyloid β (Aβ) peptide,
dsRNA transcription, GABA, dopamine, serotonin, and norepinephrine. This comprehensive exploration underscores pemirolast inhibitory actions
across disorders, emphasizing its potential therapeutic relevance in diverse pathological conditions.


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This review paper illuminates pemirolast potassium's versatile biological and therapeutic applications across various diseases. The potential
synergies of combining pemirolast with buspirone, ritanserin, theophylline, and capreomycin are explored, showcasing its ability to elicit beneficial
responses in addressing diverse ailments.