Serum omentin-1 levels in type II diabetes and its relationship with obesity

Background
Diabetes mellitus (DM) is a complex metabolic disorder, and its rapid emergence worldwide has led to its classification as an epidemic.


Aim
To increase our knowledge about omentin-1 and its relation with type 2 DM, insulin resistance, and obesity.


Patients and methods
This study included 50 patients with type 2 DM, with an age range from 40 to 70 years, who were divided into two groups (25 obese and 25 nonobese), as well as 40 age group (20 obese and 20 nonobese)-matched patients, who formed the control group. Each group was subjected to full history taking and clinical examination (fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein-cholesterol, glycosylated hemoglobin, fasting insulin, and serum omentin-1 levels). Weight and height were measured. Homeostasis model assessment insulin resistance and BMI were calculated.


Results
The study showed a significant decrease in serum omentin-1 levels in type 2 diabetic patients in comparison with the control group. Serum omentin-1 levels inversely correlated with obesity, insulin resistance, and systolic blood pressure. Negative associations were found between serum omentin-1 level and fasting glucose, glycosylated hemoglobin, and fasting lipid levels.


Conclusion
Omentin-1 may be used as a biomarker for obesity and associated metabolic and vascular disorders.