Hematopoietic cell transplantation is a complex procedure that often places significant emotional, financial, and social stress on patients, their families, and caregivers. The process is demanding, requiring extended hospital stays, frequent appointments, and ongoing posttransplant care. These challenges are compounded by uncertainty surrounding the outcome as well as financial burden. In this review, we underscore the importance of establishing comprehensive support systems for patients, their families, and caregivers throughout this journey. Providing adequate education and counseling with resources can play a vital role in minimizing the impact on patients and their families.