Predictors of mortality in severe and critical coronavirus disease 2019 patients: Mansoura University Hospital experience

Background
Coronaviruses are important human and animal pathogens. Certain demographic factors were linked with a higher rate of a severe clinical course of coronavirus disease 2019. The objective of our study was to assess predictors of mortality in patients having severe/critical coronavirus disease 2019 disease isolated in Mansoura University isolation hospital.


Results
It was found that, 115 (38.3%) patients out of 300 patients died. Mortality was significantly associated with older age (64.52 ± 12.70 for dead compared to 56.45 ± 13.29 years for survivors) but not with sex. In our study, mortality was significantly associated with smoking, hypertension, ischemic heart disease, chronic renal disease, and malignancy but not with diabetes or chronic liver disease. Additionally, specific laboratory markers, such as lower hemoglobin, platelets count, lymphocyte percentages, and lymphocyte/C-reactive protein (CRP) ratio, as well as higher neutrophil count, neutrophil percentages, N/L ratio, CRP, ferritin, lactate dehydrogenase, and aspartate transaminase (AST), need for invasive mechanical ventilation were linked to higher mortality risk. Also, mortality was statistically significant associated with increase of CT severity score.


Conclusion
The only significant predictors of mortality were higher CT severity score, higher neutrophil count, higher CRP, ferritin, lactate dehydrogenase and lower PaCO2.