Assessment of serum Stabilin-1 levels in septic patients with hematological malignancies during the neutropenic state

Abstract

Background
Macrophage Stabilin-1 (STAB-1), a phagocytic receptor that mediates efferocytosis, aids in the removal of apoptotic vascular endothelial cells that have been severely damaged by inflammation and guards against the breakdown of vascular integrity during sepsis.


Objective
The study’s objective was to measure serum levels of STAB-1 in adult patients with hematological malignancies during the neutropenic state that had any form of clinical or laboratory diagnosis of sepsis and to correlate its level with other diagnostic and prognostic parameters.


Patients and methods
This was a prospective study done on patients diagnosed with any hematological malignancy attending the Hematology Unit of Ain Shams University for 55 participants at 6 months.


Results
In comparison of STAB-1 levels between patients and control groups, there was a highly statistically significant rise in STAB-1 levels in patients than controls (P<0.001), as shown in table (10). Thirty-one (77.5%) cases were positive and showed higher STAB-1 levels in the patients’ group.


Conclusion
STAB-1 level increases in patients with hematological malignancies with sepsis in a neutropenic state. A significant positive association existed between STAB-1 level and pulse, total bilirubin, ferritin, and C-reactive protein among the studied patients. STAB-1 level is an effective measure to determine patients with hematological malignancies with sepsis in a neutropenic state.